n Feeling Pinkie Keen, Pinkie reveals her ability to predict events in the near future by interpreting various twitches and involuntary motions, which she calls her "Pinkie Sense". The citizens of Ponyville pay heed to Pinkie's predictions, according to Applejack. Twilight is skeptical of the Pinkie Sense at first, since she fails to find a scientific explanation for it, but she eventually accepts it.
In The Mysterious Mare Do Well, Pinkie saves a team of construction workers from a collapsing building as part of the "Mare Do Well" plan. After Pinkie mentions her Pinkie Sense, her tail twitches, and she pushes Rainbow Dash out of the way of a falling pot. In It's About Time, Pinkie says she can only predict immediate events and not the actual future. Her tail twitches and a flowerpot falls on Twilight's head.
Pinkie Sense is meant to be sort of a Parody of the Spidy Sense that Spiderman has in the Marvel comics Universe.